Bayer Leverkusen LEV v |  Rangers RAN | A DEFINIR | |
| 2nd Leg - Bayer Leverkusen lead 3-1 on aggregate |
FC Basel BAS v |  Eintracht Frankfurt FRA | A DEFINIR | |
| 2nd Leg - FC Basel lead 3-0 on aggregate |
FC Copenhagen COP v |  Istanbul Basaksehir IST | A DEFINIR | |
| 2nd Leg - Istanbul Basaksehir lead 1-0 on aggregate |
Internazionale INT v |  Getafe GET | A DEFINIR | |
Manchester United MUN v |  LASK Linz LAS | A DEFINIR | |
| 2nd Leg - Manchester United lead 5-0 on aggregate |
Sevilla FC SEV v |  Roma ROM | A DEFINIR | |
Shakhtar Donetsk SHAK v |  Wolfsburg WLF | A DEFINIR | |
| 2nd Leg - Shakhtar Donetsk lead 2-1 on aggregate |
Wolverhampton Wanderers WOL v |  Olympiakos OLY | A DEFINIR | |
| 2nd Leg - Tied on aggregate |